"Isotretinoin (13-cis-retinoic acid) has been used since the 1980s to treat severe recalcitrant nodular acne with good effect, but case reports and spontaneous reporting of adverse drug reactions have suggested an association between isotretinoin, depression, and suicidal behaviour," write Anders Sundström, from the Karolinska Institute in Stockholm, Sweden, and colleagues. "Observational studies have had conflicting results, however."
Severe acne is associated with the risk for suicide attempt even before treatment with isotretinoin was started, although the risk is increased during treatment and up to 6 months afterward, according to the results of a retrospective Swedish cohort study reported online first November 12 in the BMJ.
Severe Acne Linked to Suicide Risk Even Before Treatment Is Started
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