Повышенное содержание кинуреновой кислоты в ЦСЖ больных шизофренией

Schizophrenia patients show increased levels of kynurenic acid (KYNA) and its precursor kynurenine (KYN) in cerebrospinal fluid, researchers report.
They say that their findings provide further support for the hypothesis that KYNA is involved in the pathophysiology of schizophrenia.
Writing in Schizophrenia Bulletin, Sophie Erhardt (Karolinska Institute, Stockholm, Sweden) and team explain: "KYNA is an endogenous metabolite of tryptophan (TRP) produced in astrocytes and antagonizes N-methyl-D-aspartate and α7 nicotinic receptors."

Kynurenic acid levels increased in schizophrenia patients