The scientists turned to the statin medication mevastatin to find out.
In lab tests using human serotonin receptors expressed in animal cells, they showed that long-term use of the drug caused significant changes in the structure and function of serotonin cell receptors.
Adding cholesterol to cells treated with mevastatin restored them to normal.
The results represent the first report describing the effect of long-term cholesterol depletion on this type of cell receptor and suggest that chronic, low cholesterol levels in the brain might trigger anxiety and depression, the scientists say.
Link Between Cholesterol Drug and Depression
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