Субъективные ощущения и степень блокады D2-рецепторов

We found a correlation between striatal D2 receptor occupancy by olanzapine and risperidone and subjective experience, negative symptoms, and depression, in the absence of extrapyramidal symptoms. Higher doses of olanzapine were correlated with higher D2 receptor occupancy and worse subjective experience. Negative subjective experience might be more sensitive to D2 receptor occupancy than extrapyramidal symptoms. The substantial D2 receptor occupancy of olanzapine and risperidone we found is in agreement with the recent findings of others (9).

RESULTS: Subjective experience, depression, and negative symptoms were related to dopamine D2 receptor occupancy, but extrapyramidal symptoms were not.CONCLUSIONS: These results provide preliminary evidence that negative subjective experience is related to high D2 receptor occupancy. Longitudinal study is required because this relationship may have implications for dosing strategies.


Subjective Experience and Striatal Dopamine D2 Receptor Occupancy in Patients With Schizophrenia Stabilized by Olanzapine or Risperidone