This looks at the relapse risk over 5 years. These are remitted patients who go off medicines, and we're following them over time to see if their symptoms come back. Relapse was defined as rehospitalization, a very stringent criteria for relapse. And by 5 years, almost all patients had relapsed.
If you look at the group of patients who had had a first relapse and were followed out over time, 60 were at risk. Almost all had a second relapse, and then a third relapse was inevitable, happening more quickly. So relapse risk is very high, not necessarily in the first weeks after medication discontinuation or even in the first months, but over this time period symptoms will come back.
Enhancing Outcomes by Addressing Critical Challenges in the Treatment of Schizophrenia
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