потенциирование клозапина метадоном в терапии резистентной к лечению шизофрении без героиновой зависимости

We postulate a possible mechanism that might explain our patient's response. It is
possible that methadone could have acted synergically with clozapine at glutamate NMDA receptor(NMDAR) site. Clozapine and methadone are, respectively, agonist and antagonists at NMDAR site 4, 5. We think that the interaction of clozapine and methadone at NMDAR site might explain our patient's improvement, according to Shim and
colleagues' hypothesis [4]. They hypothesise that an ideal set-point of NMDAR stimulation is needed to achieve symptomatic remission. Our hypothesis is that methadone (an NMDAR antagonist)in association with clozapine (NMDAR agonist)

Methadone augmentation of clozapine in treatment-resistant schizophrenia without opiates addiction: a case report.