Рабочие дозы антипсихотиков

This bar chart illustrates the dose of antipsychotic medications needed to occupy D2-dopamine receptors at 65% (at which point the antipsychotic effect begins) and 80% (at which point EPS begins). The wider dosing margin between these occupancy levels with newer antipsychotics explains the lower EPS liability of these drugs. The quetiapine dose is divided by 100 to fit on the chart; note that it is unknown if quetiapine occupies 80% of D2-dopamine receptors at any dose, hence the low EPS liability of this compound.

Long-term Tolerability of Second-Generation Antipsychotics in Bipolar Disorder