Long-term findings for the novel antipsychotic agent asenapine did not confirm any advantage over second-generation antipsychotics for negative symptoms of schizophrenia...Extrapyramidal symptoms were "slightly" higher at 10.4% with asenapine compared with 4.1% with olanzapine. Prolactin, hepatic enzymes, lipids, glucose, and the QTC interval were similar or better with asenapine.
New Drug No Better for Negative Schizophrenia Symptoms