Исследование ГАМКергической теории депрессии

This study of 85 people is the largest such research effort on GABA and major depressive disorder to date.
It compared four groups: 25 individuals with treatment-resistant depression, 16 with major depression who were unmedicated, 19 individuals with major depression who were successfully treated with medication and had normal mood, and a control group of 25 healthy individuals.
In all groups, a thumb twitch response to transcranial magnetic (brain) stimulation (TMS) was used to measure how GABA acts physiologically in the brain. GABA receptors were found to be dysfunctional in the three groups with major depressive disorder when compared to healthy subjects.
In people who were the least responsive (treatment-resistant) to medications, the physiological effect of GABA in the brain was at its lowest.

New Drug Strategy for Depression?