Воспалительная теория шизофрении

Of great interest are findings that microglial cells—the macrophages of the brain—are activated during psychosis.6 Cells visualized with a positron emission tomography tracer (PK11195) that binds to peripheral benzodiazepine receptors, an indicator of microglia activation, were found to have greater receptor expression in patients with recent-onset schizophrenia.7 Activated microg-lia stimulate astrocytes to produce S100B, a marker of inflammation that is considered to be the equivalent of C-reactive protein in the brain.8 Serum S100B levels are elevated in patients with schizophrenia, and antipsychotics such as haloperidol (Drug information on haloperidol) and clozapine (Drug information on clozapine) have been shown to decrease S100B release from glial cells.

The Link Between Immune System Dysregulation and Schizophrenia