Partam Manalai, M.D., of the Mood and Anxiety Program in the University of Maryland Psychiatry Department and colleagues identified an association between allergy related to seasonal pollen exposure and depressive mood symptoms during the peak pollen season.
Among the 100 recruited study participants with a prior diagnosis of either major depressive disorder or bipolar disorder, approximately half had positive allergen-specific immunoglobulin E (IgE) in blood samples, indicating an allergic reaction to airborne pollen. Their allergy symptoms were measured with the Allergy Symptom Severity Assessment (ASSA) scale, and their mood symptoms were assessed using the questionnaire Structured Interview Guide for the Hamilton Depression Rating Scale, Seasonal Affective Disorders Version (SIGH-SAD).
After controlling for various confounding factors with multiple regression analysis, the researchers found that the participants' score change in the typical depression portion of the SIGH-SAD was statistically associated with worse ASSA score (p=0.008), and the change in the atypical depression portion of the SIGH-SAD was associated with IgE positivity (p=0.033). “The relationship between … [the] allergen-specific IgE and changes in mood supports a biological … mediation of the association between allergy and depression,” the authors wrote.
psychiatryonline.org
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