Нарушение клеточного цикла при шизофрении

Bahn and her colleagues are investigating disease markers in tissues such as skin, immune cells, and blood serum to find samples that give a real-time picture of the disease. Their studies of protein expression in fibroblasts (skin cells) on schizophrenia patients’ arms have identified systemic problems such as cell-cycle abnormalities (J. Proteome Res. 2010, 9, 521).

“It’s clear that schizophrenia has a very strong genetic component,” Bahn says. “Most genes are not used only in the brain. If there is an underlying abnormality at the genetic level that leads to pathology in the brain, the assumption can be made that there should also be dysregulation in the peripheral system. It may not lead to pathology, but it may reflect the pathology in the brain.”

A Systemic Look At Schizophrenia