Комбинирование клозапина с ламотриджином

Schizophrenia patients routinely are treated with polypharmacy--often with antidepressants or anticonvulsants--in attempts to improve negative symptoms, aggression, and impulsivity. Most adjuncts, however--including divalproex, antidepressants, and lithium--have shown very small, inconsistent, or no effects. The only agent with a recent meta-analysis supporting its use as augmentation in treatment-resistant schizophrenia is lamotrigine, an anticonvulsant approved for use in epilepsy...

Clozapine Augmentation with Lamotrigine